[HTML][HTML] Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis
N Guttmann-Raviv, N Shraga-Heled… - Journal of Biological …, 2007 - ASBMB
Semaphorin-3A (sema3A) is a neuropilin-1 (np1) agonist. It inhibits the binding of the 165-
amino acid form of VEGF (VEGF 165) to np1 and was reported to inhibit angiogenesis as a
result. However, we find that sema3A concentrations that inhibit the mitogenic effects of
VEGF 165 do not inhibit VEGF 165-induced phosphorylation of VEGF receptor-2 (VEGFR-2).
Furthermore, sema3A inhibits the biological effects of VEGF 121, a VEGF form that does not
bind to neuropilins and basic fibroblast growth factor, a growth factor whose activity, unlike …
amino acid form of VEGF (VEGF 165) to np1 and was reported to inhibit angiogenesis as a
result. However, we find that sema3A concentrations that inhibit the mitogenic effects of
VEGF 165 do not inhibit VEGF 165-induced phosphorylation of VEGF receptor-2 (VEGFR-2).
Furthermore, sema3A inhibits the biological effects of VEGF 121, a VEGF form that does not
bind to neuropilins and basic fibroblast growth factor, a growth factor whose activity, unlike …