[HTML][HTML] Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid β-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African …
Inefficient muscle long-chain fatty acid (LCFA) combustion is associated with insulin
resistance, but molecular links between mitochondrial fat catabolism and insulin action
remain controversial. We hypothesized that plasma acylcarnitine profiling would identify
distinct metabolite patterns reflective of muscle fat catabolism when comparing individuals
bearing a missense G304A uncoupling protein 3 (UCP3 g/a) polymorphism to controls,
because UCP3 is predominantly expressed in skeletal muscle and g/a individuals have …
resistance, but molecular links between mitochondrial fat catabolism and insulin action
remain controversial. We hypothesized that plasma acylcarnitine profiling would identify
distinct metabolite patterns reflective of muscle fat catabolism when comparing individuals
bearing a missense G304A uncoupling protein 3 (UCP3 g/a) polymorphism to controls,
because UCP3 is predominantly expressed in skeletal muscle and g/a individuals have …