[HTML][HTML] Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor …
AA Lobito, SR Ramani, I Tom, JF Bazan, E Luis… - Journal of Biological …, 2011 - ASBMB
Psoriasis is a human skin condition characterized by epidermal hyperproliferation and
infiltration of multiple leukocyte populations. In characterizing a novel insulin growth factor
(IGF)-like (IGFL) gene in mice (mIGFL), we found transcripts of this gene to be most highly
expressed in skin with enhanced expression in models of skin wounding and psoriatic-like
inflammation. A possible functional ortholog in humans, IGFL1, was uniquely and
significantly induced in psoriatic skin samples. In vitro IGFL1 expression was up-regulated in …
infiltration of multiple leukocyte populations. In characterizing a novel insulin growth factor
(IGF)-like (IGFL) gene in mice (mIGFL), we found transcripts of this gene to be most highly
expressed in skin with enhanced expression in models of skin wounding and psoriatic-like
inflammation. A possible functional ortholog in humans, IGFL1, was uniquely and
significantly induced in psoriatic skin samples. In vitro IGFL1 expression was up-regulated in …