[HTML][HTML] Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells

V Nanda, JM Miano - Journal of Biological Chemistry, 2012 - ASBMB
Smooth muscle cell (SMC) differentiation is defined largely by a number of cell-restricted
genes governed directly by the serum response factor (SRF)/myocardin (MYOCD)
transcriptional switch. Here, we describe a new SRF/MYOCD-dependent, SMC-restricted
gene known as Leiomodin 1 (Lmod1). Conventional and quantitative RT-PCRs indicate that
Lmod1 mRNA expression is enriched in SMC-containing tissues of the mouse, whereas its
two paralogs, Lmod2 and Lmod3, exhibit abundant expression in skeletal and cardiac …