OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C. difficile Infection
TJ Louie, J Emery, W Krulicki, B Byrne… - Antimicrobial agents and …, 2009 - Am Soc Microbiol
TJ Louie, J Emery, W Krulicki, B Byrne, M Mah
Antimicrobial agents and chemotherapy, 2009•Am Soc MicrobiolDuring a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were
comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts
appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was
markedly suppressive. Retention of components of the normal microflora might lower the risk
of recurrent disease.
comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts
appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was
markedly suppressive. Retention of components of the normal microflora might lower the risk
of recurrent disease.
Abstract
During a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly suppressive. Retention of components of the normal microflora might lower the risk of recurrent disease.
American Society for Microbiology