[HTML][HTML] Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2
D Bae, S Lu, CA Taglienti, AM Mercurio - Journal of biological chemistry, 2008 - ASBMB
The neuropilins-1 and-2 (NRP1 and NRP2) function as receptors for both the semaphorins
and vascular endothelial growth factor. In addition to their contribution to the development of
the nervous system, NRP1 and NRP2 have been implicated in angiogenesis and tumor
progression. Given their importance to cancer and endothelial biology and their potential as
therapeutic targets, an important issue that has not been addressed is the impact of
metabolic stress conditions characteristic of the tumor microenvironment on their expression …
and vascular endothelial growth factor. In addition to their contribution to the development of
the nervous system, NRP1 and NRP2 have been implicated in angiogenesis and tumor
progression. Given their importance to cancer and endothelial biology and their potential as
therapeutic targets, an important issue that has not been addressed is the impact of
metabolic stress conditions characteristic of the tumor microenvironment on their expression …