[HTML][HTML] Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for advanced glycation end products

N Shanmugam, YS Kim, L Lanting… - Journal of Biological …, 2003 - ASBMB
Cyclooxygenase-2 (COX-2) enzyme and its inflammatory products such as prostaglandin E
2 (PGE 2) have been implicated in the pathogenesis of several inflammatory diseases.
However their role in diabetic vascular disease is unclear. Advanced glycation end products
(AGEs) act via their receptor, RAGE, to play a major role in diabetic complications. In this
study, we investigated the effect of AGEs and S100b, a specific RAGE ligand, on the
expression of COX-2 and the molecular mechanisms involved in cultured THP-1 monocytes …