[HTML][HTML] Deconstructing tick saliva: non-protein molecules with potent immunomodulatory properties
Dendritic cells (DCs) are powerful initiators of innate and adaptive immune responses. Ticks
are blood-sucking ectoparasite arthropods that suppress host immunity by secreting
immunomodulatory molecules in their saliva. Here, compounds present in Rhipicephalus
sanguineus tick saliva with immunomodulatory effects on DC differentiation, cytokine
production, and costimulatory molecule expression were identified. R. sanguineus tick saliva
inhibited IL-12p40 and TNF-α while potentiating IL-10 cytokine production by bone marrow …
are blood-sucking ectoparasite arthropods that suppress host immunity by secreting
immunomodulatory molecules in their saliva. Here, compounds present in Rhipicephalus
sanguineus tick saliva with immunomodulatory effects on DC differentiation, cytokine
production, and costimulatory molecule expression were identified. R. sanguineus tick saliva
inhibited IL-12p40 and TNF-α while potentiating IL-10 cytokine production by bone marrow …