Pattern-recognition receptors have been highly conserved in evolution. They recognize
danger signals including both pathogen-and damage-associated molecular patterns, also
known as alarmins. Several signaling pathways leading to an inflammatory reaction as part
of an effective defensive response, are thus triggered. RAGE, a receptor initially considered
for advanced glycation end-products, is also known to be activated by several danger
signals, thus functioning as a pattern-recognition receptor. As a new member of this family …