Genetic control of cell proliferation and differentiation inDrosophilaspermatogenesis

MT Fuller - Seminars in cell & developmental biology, 1998 - Elsevier
MT Fuller
Seminars in cell & developmental biology, 1998Elsevier
Outlines of the genetic circuitry regulating male gametogenesis inDrosophilahave begun to
appear. Cessation of mitotic proliferation and onset of the meiotic program is regulated by
thebamandbgcngenes acting within male germ cells and a TGF–β class signaling cascade
in surrounding somatic cells. Onset of spermatid differentiation is regulated by a stage–and
tissue–specific transcriptional program controlled by thealy, can, miaandsagenes. A cross–
regulatory mechanism might act, in part by controlling expression of thetwinecell cycle …
Outlines of the genetic circuitry regulating male gametogenesis inDrosophilahave begun to appear. Cessation of mitotic proliferation and onset of the meiotic program is regulated by thebamandbgcngenes acting within male germ cells and a TGF–β class signaling cascade in surrounding somatic cells. Onset of spermatid differentiation is regulated by a stage– and tissue–specific transcriptional program controlled by thealy,can,miaandsagenes. A cross–regulatory mechanism might act, in part by controlling expression of thetwinecell cycle phosphatase, to delay the G2/M transition of meiosis I until genes required for spermatid differentiation have been transcribed.
Elsevier