Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
Y Hu, V Baud, M Delhase, P Zhang, T Deerinck… - Science, 1999 - science.org
Science, 1999•science.org
The oligomeric IκB kinase (IKK) is composed of three polypeptides: IKKα and IKKβ, the
catalytic subunits, and IKKγ, a regulatory subunit. IKKα and IKKβ are similar in structure and
thought to have similar function—phosphorylation of the IκB inhibitors in response to
proinflammatory stimuli. Such phosphorylation leads to degradation of IκB and activation of
nuclear factor κB transcription factors. The physiological function of these protein kinases
was explored by analysis of IKKα-deficient mice. IKKα was not required for activation of IKK …
catalytic subunits, and IKKγ, a regulatory subunit. IKKα and IKKβ are similar in structure and
thought to have similar function—phosphorylation of the IκB inhibitors in response to
proinflammatory stimuli. Such phosphorylation leads to degradation of IκB and activation of
nuclear factor κB transcription factors. The physiological function of these protein kinases
was explored by analysis of IKKα-deficient mice. IKKα was not required for activation of IKK …
The oligomeric IκB kinase (IKK) is composed of three polypeptides: IKKα and IKKβ, the catalytic subunits, and IKKγ, a regulatory subunit. IKKα and IKKβ are similar in structure and thought to have similar function—phosphorylation of the IκB inhibitors in response to proinflammatory stimuli. Such phosphorylation leads to degradation of IκB and activation of nuclear factor κB transcription factors. The physiological function of these protein kinases was explored by analysis of IKKα-deficient mice. IKKα was not required for activation of IKK and degradation of IκB by proinflammatory stimuli. Instead, loss of IKKα interfered with multiple morphogenetic events, including limb and skeletal patterning and proliferation and differentiation of epidermal keratinocytes.
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