HNF-3β is essential for node and notochord formation in mouse development
SL Ang, J Rossant - Cell, 1994 - cell.com
SL Ang, J Rossant
Cell, 1994•cell.comSummary HNF-3/?, a member of the HNF4/fork head family of transcription factors, is
expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of
this gene leads toembryonic lethality. The primary defect of HNF-3/l-'-embryos is an absence
of organized node and notochord formation, which leads to secondary defects in dorsal-
ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis
was surprisingly little affected. Although HNF-3p is required for node and notochord …
expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of
this gene leads toembryonic lethality. The primary defect of HNF-3/l-'-embryos is an absence
of organized node and notochord formation, which leads to secondary defects in dorsal-
ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis
was surprisingly little affected. Although HNF-3p is required for node and notochord …
Summary
HNF-3/?, a member of the HNF4/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads toembryonic lethality. The primary defect of HNF-3/l-‘-embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis was surprisingly little affected. Although HNF-3p is required for node and notochord formation, some organizer activity persists in the absence of these structures. HNF-3/l Is not required for the development of definitiveendoderm cells, but foregut morphogenesls Is severely affected in HNF-3/Y-‘-embryos.
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