Transgenic mice expressing human FcγRIIa have enhanced sensitivity to induced autoimmune arthritis as well as elevated Th17 cells
NC Van de Velde, PL Mottram, MS Powell, B Lim… - Immunology letters, 2010 - Elsevier
The major human Fc receptor, huFcγRIIa, is implicated in the development of autoimmune
arthritis in humans but until recently has not been studied in mouse models. We evaluated
potential roles of FcγRIIa by using transgenic mice expressing the receptor. We examined
two models of induced autoimmune arthritis pristane-induced arthritis (PIA) and collagen-
induced arthritis (CIA) as well as the anti-collagen-II antibody-induced arthritis (CAIA) model.
In the induced arthritis models PIA and CIA, the transgenic mice developed a more severe …
arthritis in humans but until recently has not been studied in mouse models. We evaluated
potential roles of FcγRIIa by using transgenic mice expressing the receptor. We examined
two models of induced autoimmune arthritis pristane-induced arthritis (PIA) and collagen-
induced arthritis (CIA) as well as the anti-collagen-II antibody-induced arthritis (CAIA) model.
In the induced arthritis models PIA and CIA, the transgenic mice developed a more severe …