[HTML][HTML] The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of FcγRIIa to modulate signaling …
LP Ganesan, H Fang, CB Marsh… - Journal of Biological …, 2003 - ASBMB
FcγRIIa is a low affinity IgG receptor uniquely expressed in human cells that promotes
phagocytosis of immune complexes and induces inflammatory cytokine gene transcription.
Recent studies have revealed that phagocytosis initiated by FcγRIIa is tightly controlled by
the inositol phosphatase SHIP-1, and the protein-tyrosine phosphatase SHP-1. Whereas the
molecular nature of SHIP-1 involvement with FcγRIIa has been well studied, it is not clear
how SHP-1 is activated by FcγRIIa to mediate its regulatory effect. Here we report that …
phagocytosis of immune complexes and induces inflammatory cytokine gene transcription.
Recent studies have revealed that phagocytosis initiated by FcγRIIa is tightly controlled by
the inositol phosphatase SHIP-1, and the protein-tyrosine phosphatase SHP-1. Whereas the
molecular nature of SHIP-1 involvement with FcγRIIa has been well studied, it is not clear
how SHP-1 is activated by FcγRIIa to mediate its regulatory effect. Here we report that …