[HTML][HTML] TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activitys⃞
Y Takahashi, N Ohoka, H Hayashi, R Sato - Journal of lipid research, 2008 - ASBMB
In the course of an effort to identify the regulators for peroxisome proliferator-activated
receptor γ (PPARγ)-dependent perilipin gene expression, we found that tribbles homolog 3
(TRB3), containing a single kinase domain without enzymatic activity, downregulates PPARγ
transcriptional activities by protein-protein interaction. We examined the role that TRB3 plays
in adipocyte differentiation in 3T3-L1 cells. TRB3 gene and protein expression was
increased during adipocyte differentiation concomitantly with an increase in the mRNA …
receptor γ (PPARγ)-dependent perilipin gene expression, we found that tribbles homolog 3
(TRB3), containing a single kinase domain without enzymatic activity, downregulates PPARγ
transcriptional activities by protein-protein interaction. We examined the role that TRB3 plays
in adipocyte differentiation in 3T3-L1 cells. TRB3 gene and protein expression was
increased during adipocyte differentiation concomitantly with an increase in the mRNA …