Developmental expression analysis of the mouse and chick orthologues of IRF6: The gene mutated in Van der Woude syndrome
AS Knight, BC Schutte, R Jiang… - … dynamics: an official …, 2006 - Wiley Online Library
AS Knight, BC Schutte, R Jiang, MJ Dixon
Developmental dynamics: an official publication of the American …, 2006•Wiley Online LibraryDevelopment of the lip and palate involves a complex series of events that requires the
close co-ordination of programmes for cell migration, growth, adhesion, differentiation, and
apoptosis (Ferguson, 1988). Failure of these processes results in orofacial clefting (OFC),
which has a prevalence of 1 in 500–2,500 live births depending on geographic origin, racial
and ethnic variation, and socio-economic status (Vanderas, 1987; Murray et al., 1997). OFC
results in considerable morbidity to affected individuals and their families as well as …
close co-ordination of programmes for cell migration, growth, adhesion, differentiation, and
apoptosis (Ferguson, 1988). Failure of these processes results in orofacial clefting (OFC),
which has a prevalence of 1 in 500–2,500 live births depending on geographic origin, racial
and ethnic variation, and socio-economic status (Vanderas, 1987; Murray et al., 1997). OFC
results in considerable morbidity to affected individuals and their families as well as …
Development of the lip and palate involves a complex series of events that requires the close co-ordination of programmes for cell migration, growth, adhesion, differentiation, and apoptosis (Ferguson, 1988). Failure of these processes results in orofacial clefting (OFC), which has a prevalence of 1 in 500–2,500 live births depending on geographic origin, racial and ethnic variation, and socio-economic status (Vanderas, 1987; Murray et al., 1997).
OFC results in considerable morbidity to affected individuals and their families as well as imposing a substantial financial and societal burden. Individuals who exhibit OFC may experience problems with eating, speaking, and hearing, which can be corrected to varying degrees by surgery, dental treatment, and speech therapy. In addition, the altered facial appearance may lead to psychosocial consequences. The complex aetiology of OFC does, however, afford significant
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