Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice
X Xiong, X Wang, Y Lu, E Wang, Z Zhang, J Yang… - Journal of …, 2014 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is characterized by an
increase in hepatic triglyceride (TG) contents. The prevalence of NAFLD is increased with
aging. However, the molecular mechanism for aging-induced fatty liver remains poorly
understood. Methods Hepatic TG contents and gene expression profiles were analyzed in
body weight-matched young (2 months), middle (8 months) and old (18 months) C57BL/6
mice. Endoplasmic reticulum (ER) stress and farnesoid X receptor (FXR) expression were …
increase in hepatic triglyceride (TG) contents. The prevalence of NAFLD is increased with
aging. However, the molecular mechanism for aging-induced fatty liver remains poorly
understood. Methods Hepatic TG contents and gene expression profiles were analyzed in
body weight-matched young (2 months), middle (8 months) and old (18 months) C57BL/6
mice. Endoplasmic reticulum (ER) stress and farnesoid X receptor (FXR) expression were …