[HTML][HTML] RORα regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR
The staggerer mice carry a deletion in the RORα gene and have a prolonged humoral
response, overproduce inflammatory cytokines, and are immunodeficient. Furthermore, the
staggerer mice display lowered plasma apoA-I/-II, decreased plasma high density
lipoprotein cholesterol and triglycerides, and develop hypo-α-lipoproteinemia and
atherosclerosis. However, relatively little is known about RORα in the context of target
tissues, target genes, and lipid homeostasis. For example, RORα is abundantly expressed in …
response, overproduce inflammatory cytokines, and are immunodeficient. Furthermore, the
staggerer mice display lowered plasma apoA-I/-II, decreased plasma high density
lipoprotein cholesterol and triglycerides, and develop hypo-α-lipoproteinemia and
atherosclerosis. However, relatively little is known about RORα in the context of target
tissues, target genes, and lipid homeostasis. For example, RORα is abundantly expressed in …