[HTML][HTML] Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor α expression and fatty acid oxidation and prevents …
K Drosatos, Z Drosatos-Tampakaki, R Khan… - Journal of Biological …, 2011 - ASBMB
Septic shock results from bacterial infection and is associated with multi-organ failure, high
mortality, and cardiac dysfunction. Sepsis causes both myocardial inflammation and energy
depletion. We hypothesized that reduced cardiac energy production is a primary cause of
ventricular dysfunction in sepsis. The JNK pathway is activated in sepsis and has also been
implicated in impaired fatty acid oxidation in several tissues. Therefore, we tested whether
JNK activation inhibits cardiac fatty acid oxidation and whether blocking JNK would restore …
mortality, and cardiac dysfunction. Sepsis causes both myocardial inflammation and energy
depletion. We hypothesized that reduced cardiac energy production is a primary cause of
ventricular dysfunction in sepsis. The JNK pathway is activated in sepsis and has also been
implicated in impaired fatty acid oxidation in several tissues. Therefore, we tested whether
JNK activation inhibits cardiac fatty acid oxidation and whether blocking JNK would restore …