[HTML][HTML] Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE* 3-Leiden. CETP mice
S Bijland, EJ Pieterman, ACE Maas… - Journal of biological …, 2010 - ASBMB
The peroxisome proliferator-activated receptor alpha (PPARα) activator fenofibrate efficiently
decreases plasma triglycerides (TG), which is generally attributed to enhanced very low
density lipoprotein (VLDL)-TG clearance and decreased VLDL-TG production. However,
because data on the effect of fenofibrate on VLDL production are controversial, we aimed to
investigate in (more) detail the mechanism underlying the TG-lowering effect by studying
VLDL-TG production and clearance using APOE* 3-Leiden. CETP mice, a unique mouse …
decreases plasma triglycerides (TG), which is generally attributed to enhanced very low
density lipoprotein (VLDL)-TG clearance and decreased VLDL-TG production. However,
because data on the effect of fenofibrate on VLDL production are controversial, we aimed to
investigate in (more) detail the mechanism underlying the TG-lowering effect by studying
VLDL-TG production and clearance using APOE* 3-Leiden. CETP mice, a unique mouse …