Hepatic HCV RNA before and after treatment with interferon alone or combined with ribavirin

JG McHutchison, T Poynard, R Esteban-Mur, GL Davis… - Hepatology, 2002 - Elsevier
The clinical use of measuring hepatic hepatitis C virus (HCV) RNA before and after therapy
in patients with chronic hepatitis C has been assessed in a number of small clinical trials.
Viral clearance from the liver may be a better marker of long-term response than eradication
of serum HCV RNA. The aim of this study was to evaluate quantitative hepatic HCV-RNA
measurements before and after antiviral therapy. Two thousand eighty-nine chronic hepatitis
C patients were enrolled in 3 published clinical trials evaluating interferon alfa-2b alone or …