IFNL4-ΔG Genotype Is Associated With Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated With Sofosbuvir and Ribavirin
EG Meissner, D Bon, L Prokunina-Olsson… - The Journal of …, 2014 - academic.oup.com
The Journal of infectious diseases, 2014•academic.oup.com
Response to pegylated interferon-alpha and ribavirin (IFN-α/RBV) treatment for chronic
hepatitis C virus (HCV) infection is influenced by host genetic factors, but their role for IFN-α–
free, direct-acting antiviral (DAA) regimens is unclear. An exonic deletion allele (IFNL4-ΔG)
bolsters the established association with IFN-α/RBV therapy treatment outcome of another
IFNL4 variant, rs12979860, which is located upstream of IFNL3 (IL28B). We report that in
patients treated with the DAA sofosbuvir along with RBV, IFNL4-ΔG is associated with …
hepatitis C virus (HCV) infection is influenced by host genetic factors, but their role for IFN-α–
free, direct-acting antiviral (DAA) regimens is unclear. An exonic deletion allele (IFNL4-ΔG)
bolsters the established association with IFN-α/RBV therapy treatment outcome of another
IFNL4 variant, rs12979860, which is located upstream of IFNL3 (IL28B). We report that in
patients treated with the DAA sofosbuvir along with RBV, IFNL4-ΔG is associated with …
Abstract
Response to pegylated interferon-alpha and ribavirin (IFN-α/RBV) treatment for chronic hepatitis C virus (HCV) infection is influenced by host genetic factors, but their role for IFN-α–free, direct-acting antiviral (DAA) regimens is unclear. An exonic deletion allele (IFNL4-ΔG) bolsters the established association with IFN-α/RBV therapy treatment outcome of another IFNL4 variant, rs12979860, which is located upstream of IFNL3 (IL28B). We report that in patients treated with the DAA sofosbuvir along with RBV, IFNL4-ΔG is associated with slower early viral decay, due to slower loss of free virus (P = .039) and decreased drug efficacy (P = .048), suggesting functional relevance of IFN-λ4 in IFN-α–free DAA therapies.
Oxford University Press