Acne is one of the most common dermatologic diseases in the developed regions of the
world, affecting a large percentage of the population. Despite the great improvement in the
number and quality of studies of the molecular etiology of this disease in the past 3 decades,
the detailed molecular pathogenesis and the cause of the large individual variations in
severity of skin symptoms remain unknown. The roles of genetic inheritance and special
genetic susceptibility and protective factors have been suggested for over 100 years, but …