Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system
MJ Perlow, WJ Freed, BJ Hoffer, A Seiger, L Olson… - Science, 1979 - science.org
MJ Perlow, WJ Freed, BJ Hoffer, A Seiger, L Olson, RJ Wyatt
Science, 1979•science.orgIn order to determine if brain tissue grafts can provide functional input to recipient central
nervous system tissue, fetal rat dopamine-containing neurons were implanted adjacent to
the caudate nucleus of adult recipients whose endogenous dopaminergic input had been
destroyed. The grafts showed good survival and axonal outgrowth. Motor abnormalities,
which had been induced by the destruction of the endogenous dopaminergic input to the
caudate, were significantly reduced after grafting of the fetal brain tissue. These data …
nervous system tissue, fetal rat dopamine-containing neurons were implanted adjacent to
the caudate nucleus of adult recipients whose endogenous dopaminergic input had been
destroyed. The grafts showed good survival and axonal outgrowth. Motor abnormalities,
which had been induced by the destruction of the endogenous dopaminergic input to the
caudate, were significantly reduced after grafting of the fetal brain tissue. These data …
In order to determine if brain tissue grafts can provide functional input to recipient central nervous system tissue, fetal rat dopamine-containing neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed. The grafts showed good survival and axonal outgrowth. Motor abnormalities, which had been induced by the destruction of the endogenous dopaminergic input to the caudate, were significantly reduced after grafting of the fetal brain tissue. These data suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue.
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