[HTML][HTML] Tumor necrosis factor-α and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation
L Fernandez, S Rodriguez, H Huang, A Chora… - Experimental …, 2008 - Elsevier
OBJECTIVE: Homeostasis of the hematopoietic compartment is challenged and maintained
during conditions of stress by mechanisms that are poorly defined. To understand how the
bone marrow (BM) microenvironment influences hematopoiesis, we explored the role of
Notch signaling and BM endothelial cells in providing microenvironmental cues to
hematopoietic cells in the presence of inflammatory stimuli. MATERIALS AND METHODS:
The human BM endothelial cell line (BMEC) and primary human BM endothelial cells were …
during conditions of stress by mechanisms that are poorly defined. To understand how the
bone marrow (BM) microenvironment influences hematopoiesis, we explored the role of
Notch signaling and BM endothelial cells in providing microenvironmental cues to
hematopoietic cells in the presence of inflammatory stimuli. MATERIALS AND METHODS:
The human BM endothelial cell line (BMEC) and primary human BM endothelial cells were …