[HTML][HTML] Off the beaten pathway: the complex cross talk between Notch and NF-κB
C Osipo, TE Golde, BA Osborne, LA Miele - Laboratory investigation, 2008 - Elsevier
The canonical Notch pathway that has been well characterized over the past 25 years is
relatively simple compared to the plethora of recently published data suggesting non-
canonical signaling mechanisms and cross talk with other pathways. The manner in which
other pathways cross talk with Notch signaling appears to be extraordinarily complex and,
not surprisingly, context-dependent. While the physiological relevance of many of these
interactions remains to be established, there is little doubt that Notch signaling is integrated …
relatively simple compared to the plethora of recently published data suggesting non-
canonical signaling mechanisms and cross talk with other pathways. The manner in which
other pathways cross talk with Notch signaling appears to be extraordinarily complex and,
not surprisingly, context-dependent. While the physiological relevance of many of these
interactions remains to be established, there is little doubt that Notch signaling is integrated …