[HTML][HTML] Efficacy and duration of immunity after yellow fever vaccination: systematic review on the need for a booster every 10 years

E Gotuzzo, S Yactayo, E Córdova - The American journal of tropical …, 2013 - ncbi.nlm.nih.gov
E Gotuzzo, S Yactayo, E Córdova
The American journal of tropical medicine and hygiene, 2013ncbi.nlm.nih.gov
Current regulations stipulate a yellow fever (YF) booster every 10 years. We conducted a
systematic review of the protective efficacy and duration of immunity of YF vaccine in
residents of disease-endemic areas and in travelers to assess the need for a booster in
these two settings and in selected populations (human immunodeficiency virus–infected
persons, infants, children, pregnant women, and severely malnourished persons). Thirty-six
studies and 22 reports were included. We identified 12 studies of immunogenicity, 8 of …
Abstract
Current regulations stipulate a yellow fever (YF) booster every 10 years. We conducted a systematic review of the protective efficacy and duration of immunity of YF vaccine in residents of disease-endemic areas and in travelers to assess the need for a booster in these two settings and in selected populations (human immunodeficiency virus–infected persons, infants, children, pregnant women, and severely malnourished persons). Thirty-six studies and 22 reports were included. We identified 12 studies of immunogenicity, 8 of duration of immunity, 8 of vaccine response in infants and children, 7 of human-immunodeficiency virus–infected persons, 2 of pregnant women, and 1 of severely malnourished children. Based on currently available data, a single dose of YF vaccine is highly immunogenic and confers sustained life-long protective immunity against YF. Therefore, a booster dose of YF vaccine is not needed. Special considerations for selected populations are detailed.
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