S1PR2 links germinal center confinement and growth regulation

JA Green, JG Cyster - Immunological reviews, 2012 - Wiley Online Library
JA Green, JG Cyster
Immunological reviews, 2012Wiley Online Library
Germinal centers (GCs) are sites of rapid B‐cell proliferation and somatic mutation. These
ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell
migration and interaction dynamics underlying GC B‐cell selection events are currently
under intense scrutiny. In recent study, we identified a role for a migration inhibitory receptor,
S1PR2, in promoting GC B‐cell confinement to GCs. S1PR2 also dampens Akt activation
and deficiency in S1PR2 or components of its signaling pathway result in a loss of growth …
Summary
Germinal centers (GCs) are sites of rapid B‐cell proliferation and somatic mutation. These ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell migration and interaction dynamics underlying GC B‐cell selection events are currently under intense scrutiny. In recent study, we identified a role for a migration inhibitory receptor, S1PR2, in promoting GC B‐cell confinement to GCs. S1PR2 also dampens Akt activation and deficiency in S1PR2 or components of its signaling pathway result in a loss of growth control in chronically stimulated mucosal GCs. Herein, we detail present understanding of S1PR2 and S1P biology as it pertains to GC B cells and place this information in the context of a current model of GC function.
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