Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts
MJ Gibson, DT Krieger, HM Charlton, EA Zimmerman… - Science, 1984 - science.org
MJ Gibson, DT Krieger, HM Charlton, EA Zimmerman, AJ Silverman, MJ Perlow
Science, 1984•science.orgAdult female hypogonadal mice, in whom hypogonadism is secondary to a genetic
deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating,
pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal
preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of
adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons
in the grafts and GnRH-containing processes extending to the lateral median eminence of …
deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating,
pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal
preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of
adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons
in the grafts and GnRH-containing processes extending to the lateral median eminence of …
Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.
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