[HTML][HTML] Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II

Z Xiao, S Zhang, BS Magenheimer, J Luo… - Journal of biological …, 2008 - ASBMB
Polycystin-1 (PC1) may play an important role in skeletogenesis through regulation of the
bone-specific transcription factor Runx2-II. In the current study we found that PC1 co-
localizes with the calcium channel polycystin-2 (PC2) in primary cilia of MC3T3-E1
osteoblasts. To establish the role of Runx2-II in mediating PC1 effects on bone, we crossed
heterozygous Pkd1 m1Bei and Runx2-II mice to create double heterozygous mice
(Pkd1+/m1Bei/Runx2-II+/-) deficient in both PC1 and Runx2-II. Pkd1+/m1Bei/Runx2-II+ …