[HTML][HTML] Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-methyl-D-aspartate receptor
GA Rameau, LY Chiu, EB Ziff - Journal of Biological Chemistry, 2004 - ASBMB
At glutamatergic synapses, the scaffolding protein PSD95 links the neuronal isoform of nitric-
oxide synthase (nNOS) to the N-methyl-d-aspartate (NMDA) receptor. Phosphorylation of
nNOS at serine 847 (Ser 847) by the calcium-calmodulin protein kinase II (CaMKII) inhibits
nNOS activity, possibly by blocking the binding of Ca 2+-CaM. Here we show that the NMDA
mediates a novel bidirectional regulation of Ser 847 phosphorylation. nNOS phosphorylated
at Ser 847 colocalizes with the NMDA receptor at spines of cultured hippocampal neurons …
oxide synthase (nNOS) to the N-methyl-d-aspartate (NMDA) receptor. Phosphorylation of
nNOS at serine 847 (Ser 847) by the calcium-calmodulin protein kinase II (CaMKII) inhibits
nNOS activity, possibly by blocking the binding of Ca 2+-CaM. Here we show that the NMDA
mediates a novel bidirectional regulation of Ser 847 phosphorylation. nNOS phosphorylated
at Ser 847 colocalizes with the NMDA receptor at spines of cultured hippocampal neurons …