Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria
E Belnoue, FTM Costa, AM Vigário, T Voza… - Infection and …, 2003 - Am Soc Microbiol
Infection and immunity, 2003•Am Soc Microbiol
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice.
Brain-sequestered CD8+ T cells are responsible for this pathology. We have evaluated the
role of CCR2, a chemokine receptor expressed on CD8+ T cells. Infected CCR2-deficient
mice were as susceptible to cerebral malaria as wild-type mice were, and CD8+ T-cell
migration to the brain was not abolished.
Brain-sequestered CD8+ T cells are responsible for this pathology. We have evaluated the
role of CCR2, a chemokine receptor expressed on CD8+ T cells. Infected CCR2-deficient
mice were as susceptible to cerebral malaria as wild-type mice were, and CD8+ T-cell
migration to the brain was not abolished.
Abstract
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8+ T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8+ T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8+ T-cell migration to the brain was not abolished.
American Society for Microbiology