[HTML][HTML] Role of complement and perspectives for intervention in transplantation
G Chen, S Chen, X Chen - Immunobiology, 2013 - Elsevier
The complement cascade is a major contributor to the innate immune response. It has now
been well accepted that complement plays a critical role in hyperacute rejection and acute
antibody-mediated rejection of transplanted organ. There is also increasing evidence that
complement proteins contribute to the pathogenesis of organ ischemia–reperfusion injury,
and even to cell-mediated rejection. Furthermore, the chemoattractants C3a and C5a and
the terminal membrane attack complex that are generated by complement activation can …
been well accepted that complement plays a critical role in hyperacute rejection and acute
antibody-mediated rejection of transplanted organ. There is also increasing evidence that
complement proteins contribute to the pathogenesis of organ ischemia–reperfusion injury,
and even to cell-mediated rejection. Furthermore, the chemoattractants C3a and C5a and
the terminal membrane attack complex that are generated by complement activation can …