[HTML][HTML] MOCA induces membrane spreading by activating Rac1
K Namekata, Y Enokido, K Iwasawa… - Journal of Biological …, 2004 - ASBMB
The modifier of cell adhesion protein (MOCA), or Dock3, initially identified as presenilin-
binding protein (PBP), belongs to the Dock180 family of proteins and is localized specifically
in neurons. Here we demonstrate that MOCA binds to Rac1 and enhances its activity, which
leads to the activation of c-Jun NH 2-terminal kinase (JNK) and causes changes in cell
morphology. Farnesylated MOCA, which is localized in the plasma membrane, enhances
the activation of Rac1 and JNK more markedly than wild-type MOCA, and cells expressing …
binding protein (PBP), belongs to the Dock180 family of proteins and is localized specifically
in neurons. Here we demonstrate that MOCA binds to Rac1 and enhances its activity, which
leads to the activation of c-Jun NH 2-terminal kinase (JNK) and causes changes in cell
morphology. Farnesylated MOCA, which is localized in the plasma membrane, enhances
the activation of Rac1 and JNK more markedly than wild-type MOCA, and cells expressing …