OBJECTIVE: Serum alanine transaminase (ALT) and aspartate transaminase (AST) levels
are commonly used as biochemical indicators of hepatocellular injury but can also detect
occult muscle disease. High concomitant serum creatine phosphokinase (CPK) levels can
point to muscle as the source of high transaminase levels. Nevertheless, clinicians may be
reluctant to attribute high transaminase levels to muscle. METHODS: Study patients were
boys with a genetic or biopsy-confirmed dystrophinopathy whose concomitant serum CPK …