[HTML][HTML] The classical complement pathway in transplantation: unanticipated protective effects of C1q and role in inductive antibody therapy
K Csencsits, BE Burrell, G Lu, EJ Eichwald… - American Journal of …, 2008 - Elsevier
Though complement (C) deposition within the transplant is associated with allograft
rejection, the pathways employed have not been established. In addition, evidence suggests
that C-mediated cytolysis may be necessary for the tolerance-inducing activities of mAb
therapies. Hence, we assessed the role of the classical C pathway in acute allograft
rejection and its requirement for experimental mAb therapies. C1q-deficient (C1q-/-)
recipients rejected allografts at a faster rate than wild-type (WT) recipients. This rejection …
rejection, the pathways employed have not been established. In addition, evidence suggests
that C-mediated cytolysis may be necessary for the tolerance-inducing activities of mAb
therapies. Hence, we assessed the role of the classical C pathway in acute allograft
rejection and its requirement for experimental mAb therapies. C1q-deficient (C1q-/-)
recipients rejected allografts at a faster rate than wild-type (WT) recipients. This rejection …