All good things must come to an end: how is Notch signaling turned off?
R Kopan - Science's STKE, 1999 - science.org
Science's STKE, 1999•science.org
Turning off signaling pathways can be just as important for proper biological regulation as
turning them on. The Notch signaling pathway controls development of the nervous system
in Drosophila. Proteolysis of Notch appears to initiate signaling, but further proteolysis may
also terminate signals from this pathway. Kopan discusses mechanisms that limit signaling
by Notch, including recent evidence that degradation of specifically targeted proteins by the
proteasome is required.
turning them on. The Notch signaling pathway controls development of the nervous system
in Drosophila. Proteolysis of Notch appears to initiate signaling, but further proteolysis may
also terminate signals from this pathway. Kopan discusses mechanisms that limit signaling
by Notch, including recent evidence that degradation of specifically targeted proteins by the
proteasome is required.
Turning off signaling pathways can be just as important for proper biological regulation as turning them on. The Notch signaling pathway controls development of the nervous system in Drosophila. Proteolysis of Notch appears to initiate signaling, but further proteolysis may also terminate signals from this pathway. Kopan discusses mechanisms that limit signaling by Notch, including recent evidence that degradation of specifically targeted proteins by the proteasome is required.
AAAS