Maternal immunity and prevention of congenital cytomegalovirus infection

KB Fowler, S Stagno, RF Pass - Jama, 2003 - jamanetwork.com
ContextVaccine development to prevent congenital cytomegalovirus (CMV) infection has
been impeded by the uncertainty over whether maternal immunity protects the fetus.
ObjectiveTo determine whether the presence of maternal antibodies to CMV significantly
reduces the risk of congenital CMV infection in future pregnancies. Design, Setting, and
ParticipantsCohort study of 3461 multiparous women from a population with a high rate of
congenital CMV infection who delivered newborns screened for congenital CMV infection …