Protein turnover on the scale of the proteome
MK Doherty, RJ Beynon - Expert review of proteomics, 2006 - Taylor & Francis
Expert review of proteomics, 2006•Taylor & Francis
Protein turnover is a neglected dimension in postgenomic studies, defining the dynamics of
changes in protein expression and forging a link between transcriptome, proteome and
metabolome. Recent advances in postgenomic technologies have led to the development of
new proteomic techniques to measure protein turnover on a proteome-wide scale. These
methods are driven by stable isotope metabolic labeling of cells in culture or in intact
animals. This review considers the merits and difficulties of different methods that allow …
changes in protein expression and forging a link between transcriptome, proteome and
metabolome. Recent advances in postgenomic technologies have led to the development of
new proteomic techniques to measure protein turnover on a proteome-wide scale. These
methods are driven by stable isotope metabolic labeling of cells in culture or in intact
animals. This review considers the merits and difficulties of different methods that allow …
Protein turnover is a neglected dimension in postgenomic studies, defining the dynamics of changes in protein expression and forging a link between transcriptome, proteome and metabolome. Recent advances in postgenomic technologies have led to the development of new proteomic techniques to measure protein turnover on a proteome-wide scale. These methods are driven by stable isotope metabolic labeling of cells in culture or in intact animals. This review considers the merits and difficulties of different methods that allow access to proteome dynamics.
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