Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical
aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous
lesions. This paper tabulates markers of prostate field cancerization known to date and
discusses their potential clinical value in the analysis of prostate biopsies, including
diagnosis, monitoring progression during active surveillance, and assessing efficacy of
presurgical neoadjuvant and focal therapeutic interventions.