Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted
phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a
multifunctional protein. OPN has been found to be expressed in various cell types and
species with many physiologic and pathologic functions. OPN has emerged as a potential
biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of
OPN in cardiovascular disease, specifically in vascular and valvular heart disease …