AMP-activated protein kinase regulates HNF4α transcriptional activity by inhibiting dimer formation and decreasing protein stability
YH Hong, US Varanasi, W Yang, T Leff - Journal of Biological Chemistry, 2003 - ASBMB
AMP-activated protein kinase (AMPK) is the central component of a cellular signaling system
that regulates multiple metabolic enzymes and pathways in response to reduced
intracellular energy levels. The transcription factor hepatic nuclear factor 4α (HNF4α) is an
orphan nuclear receptor that regulates the expression of genes involved in energy
metabolism in the liver, intestine, and endocrine pancreas. Inheritance of a single null allele
of HNF4α causes diabetes in humans. Here we demonstrate that AMPK directly …
that regulates multiple metabolic enzymes and pathways in response to reduced
intracellular energy levels. The transcription factor hepatic nuclear factor 4α (HNF4α) is an
orphan nuclear receptor that regulates the expression of genes involved in energy
metabolism in the liver, intestine, and endocrine pancreas. Inheritance of a single null allele
of HNF4α causes diabetes in humans. Here we demonstrate that AMPK directly …
