Viral vector tropism for supporting cells in the developing murine cochlea

AM Sheffield, SP Gubbels, MS Hildebrand, SS Newton… - Hearing research, 2011 - Elsevier
Gene-based therapeutics are being developed as novel treatments for genetic hearing loss.
One roadblock to effective gene therapy is the identification of vectors which will safely
deliver therapeutics to targeted cells. The cellular heterogeneity that exists within the
cochlea makes viral tropism a vital consideration for effective inner ear gene therapy. There
are compelling reasons to identify a viral vector with tropism for organ of Corti supporting
cells. Supporting cells are the primary expression site of connexin 26 gap junction proteins …