Furosemide was injected intravenously in anesthetized cats while the endocochlear
potential (EP) and tuning curves from fibers of the auditory nerve were simultaneously
monitored in the same ear. The characteristic frequencies (CF's) of the fibers studied ranged
from 0.25 to 28 kHz. Furosemide administration produced reversible, dose-related
decreases in the EP which were accompanied by threshold elevations and alterations in the
tuning curves of auditory nerve fibers. There was approximately l dB of threshold elevation …