Solid tumors not only comprise malignant cells but also other nonmalignant cell types,
forming a unique microenvironment that can strongly influence the behavior of tumor cells.
Recent advances in the understanding of cancer biology have highlighted the functional role
of semaphorins. In fact, semaphorins form a family of molecular signals known to guide and
control cell migration during embryo development and in adults. Tumor cells express
semaphorins as well as their receptors, plexins and neuropilins. It has been shown that …