Platelets are dynamic cells with activities that extend beyond thrombosis including an
important role in initiating and sustaining vascular inflammation. A role for platelets has been
described in many physiologic and pathophysiologic processes such as atherosclerosis,
stem cell trafficking, tumor metastasis, and arthritis. Platelet activation at sites of an intact
inflamed endothelium contributes to vascular inflammation and vascular wall remodeling.
Platelets secrete a wide array of preformed and synthesized inflammatory mediators upon …