[CITATION][C] Morphological aspects of renal homograft rejection

KA Porter - British medical bulletin, 1965 - academic.oup.com
KA Porter
British medical bulletin, 1965academic.oup.com
Sixty years ago technically satisfactory renal transplants were first achieved (Carrel &
Guthrie, 1905; Floresco, 1905). In the next decade it became clear that the behaviour of
homografts differs fundamentally from that of autotransplants. Whereas the latter survive for
long periods and show a minimal and transient cellular infiltration, homotransplants (with
few exceptions—see section la) function for only a few days and show progressive
infiltration with cells, followed by necrosis of the parenchyma.
Sixty years ago technically satisfactory renal transplants were first achieved (Carrel & Guthrie, 1905; Floresco, 1905). In the next decade it became clear that the behaviour of homografts differs fundamentally from that of autotransplants. Whereas the latter survive for long periods and show a minimal and transient cellular infiltration, homotransplants (with few exceptions—see section la) function for only a few days and show progressive infiltration with cells, followed by necrosis of the parenchyma.
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