Cell models for prion diseases are mainly of neuronal origin. However, the pathological
isoform PrPSc of cellular prion protein (PrPc) and prion infectivity are found in a variety of
extraneural tissues in prion diseases. Although many cell types are not able to propagate
PrPSc, little is known about cellular mechanism counteracting prion infection. It is desirable
to identify neuronal or non-neuronal cell models that restrict PrPSc generation or propagate
PrPSc only transiently. Neuroendocrine cells are derived from tumours forming the interface …