[HTML][HTML] Glycosphingolipids internalized via caveolar-related endocytosis rapidly merge with the clathrin pathway in early endosomes and form microdomains for …

DK Sharma, A Choudhury, RD Singh… - Journal of Biological …, 2003 - ASBMB
We have previously demonstrated that glycosphingolipids are internalized from the plasma
membrane of human skin fibroblasts by a clathrin-independent, caveolar-related mechanism
and are subsequently transported to the Golgi apparatus by a process that is dependent on
microtubules, phosphatidylinositol 3-kinase, Rab7, and Rab9. Here we characterized the
early steps of intracellular transport of a fluorescent glycosphingolipid analog, BODIPY-
lactosylceramide (LacCer), and compared this to fluorescent transferrin (Tfn), a well …