[HTML][HTML] Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons
JR McGuire, J Rong, SH Li, XJ Li - Journal of Biological Chemistry, 2006 - ASBMB
Huntingtin-associated protein-1 (HAP1) was initially identified as an interacting partner of
huntingtin, the Huntington disease protein. Unlike huntingtin that is ubiquitously expressed
throughout the brain and body, HAP1 is enriched in neurons, suggesting that its dysfunction
could contribute to Huntington disease neuropathology. Growing evidence has
demonstrated that HAP1 and huntingtin are anterogradely transported in axons and that the
abnormal interaction between mutant huntingtin and HAP1 may impair axonal transport …
huntingtin, the Huntington disease protein. Unlike huntingtin that is ubiquitously expressed
throughout the brain and body, HAP1 is enriched in neurons, suggesting that its dysfunction
could contribute to Huntington disease neuropathology. Growing evidence has
demonstrated that HAP1 and huntingtin are anterogradely transported in axons and that the
abnormal interaction between mutant huntingtin and HAP1 may impair axonal transport …